Written by 
Before looking at SportsbookWire staff’s Week 10 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com.
At 7-1 ATS, the Detroit Lions (7-1 straight up) feature the NFL’s top ATS record heading into Week 10. They play at the Houston Texans (6-3 SU, 3-5-1 ATS) in the Sunday Night Football game (8:20 p.m. ET / NBC). As of Thursday at 7:31 a.m. ET, BetMGM Sportsbook lists Detroit as 3.5-point favorites.
The Washington Commanders have the next best ATS record at 7-1-1, while the Indianapolis Colts are 7-2 ATS.
On the other side of the spectrum are the Tennessee Titans, who have been the top team to fade — bet against — at 1-7 ATS. Not far behind are the Carolina Panthers (2-7 ATS), the Dallas Cowboys and Miami Dolphins (both 2-6 ATS) and the Seattle Seahawks (2-6-1 ATS).
The Baltimore Ravens are the top Over team at 8-1, while the Panthers and Tampa Bay Buccaneers are both 7-2 O/U.
The LA Chargers improved their top Under mark to 1-7 after a 27-10 win at the Cleveland Browns with an O/U line of 42. The Texans are the next best Under team at 2-7.
Four teams have byes this week. They are the Browns, Green Bay Packers, Las Vegas Raiders and Seahawks.
NFL Week 10 staff picks
Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds and check out more NFL expert picks and predictions from SportsbookWire.com.
WIN YOUR FANTASY FOOTBALL LEAGUE!
The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Save 25% off the Internet’s best-kept secret. Subscribe now!
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on Twitter/X and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside.